{"id":812,"date":"2020-12-06T18:50:58","date_gmt":"2020-12-06T18:50:58","guid":{"rendered":"https:\/\/www.micronanotech.ro\/evaluarea-potentialului-de-exploatare-a-materialelor-poroase-in-tratarea-disbiozelor-microbiotei\/"},"modified":"2021-03-04T12:44:55","modified_gmt":"2021-03-04T12:44:55","slug":"evaluarea-potentialului-de-exploatare-a-materialelor-poroase-in-tratarea-disbiozelor-microbiotei","status":"publish","type":"post","link":"https:\/\/www.micronanotech.ro\/en\/evaluarea-potentialului-de-exploatare-a-materialelor-poroase-in-tratarea-disbiozelor-microbiotei\/","title":{"rendered":"Evaluation of the exploitation potential of porous materials in the treatment of microbiota dysbiosis"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row equal_height=&#8221;yes&#8221;][vc_column offset=&#8221;vc_col-md-8&#8243;][vc_single_image image=&#8221;665&#8243; img_size=&#8221;full&#8221;][\/vc_column][vc_column css=&#8221;.vc_custom_1605772046492{padding-top: 15px !important;background-color: #f3fbfe !important;}&#8221; offset=&#8221;vc_col-md-4&#8243;]<style>.porto-info-listf4327c02baeb14e50db6da5ea25e50c3 i { color: #1ab7ea;font-size: 20px; }<\/style><ul class=\"porto-info-list  porto-info-listf4327c02baeb14e50db6da5ea25e50c3 wpb_custom_0245a87303d849201cd886c7f565cc53\"><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-grid\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Abbreviation: <\/strong>PREMISE<\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-tag\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Project code:<\/strong> PN-III-P2-2.1-PED-2019-4018<\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-note\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Contract number: <\/strong>524PED\/2020<\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-calendar\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Start<\/strong>: 23 October 2020<br \/>\n<strong>End:<\/strong> 21 October 2022<\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-hourglass\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Duration<\/strong>: 24 months<\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-wallet\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Budget:<\/strong> 600.000,00 RON<\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-user\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Contracting authority:<\/strong> <a href=\"https:\/\/uefiscdi.gov.ro\/\" target=\"_blank\" rel=\"noopener noreferrer\">UEFISCDI &#8211; Unitatea Executiv\u0103 pentru Finan\u021barea \u00cenv\u0103\u021b\u0103m\u00e2ntului Superior, a Cercet\u0103rii, Dezvolt\u0103rii \u0219i Inov\u0103rii<\/a><\/div><\/li><li class=\"porto-info-list-item  wpb_custom_eade0171093a7591372ccf9372738e3d\"><i class=\"porto-info-icon Simple-Line-Icons-home\"><\/i><div class=\"porto-info-list-item-desc\"><strong>Coordinating institution<\/strong>: UPB-CNMN \u2013 University POLITEHNICA of Bucharest \u2013<br \/>\nNational Center for Micro and Nanomaterials<\/div><\/li><\/ul>[\/vc_column][\/vc_row][vc_row el_class=&#8221;padding-65&#8243;][vc_column][vc_tabs type=&#8221;tabs-simple&#8221; icon_style=&#8221;featured-boxes-style-6&#8243; icon_effect=&#8221;featured-box-effect-6&#8243;][vc_tab show_icon=&#8221;yes&#8221; icon_type=&#8221;simpleline&#8221; icon_simpleline=&#8221;Simple-Line-Icons-people&#8221; title=&#8221;Project team&#8221; tab_id=&#8221;7224df3a-ec68-8&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;614&#8243; img_size=&#8221;full&#8221; css=&#8221;.vc_custom_1605772093012{margin-bottom: 35px !important;}&#8221;][\/vc_column_inner][vc_column_inner el_class=&#8221;echipa&#8221; width=&#8221;1\/2&#8243;][vc_column_text]<strong>Coordinator \u2013 <\/strong>University POLITEHNICA of Bucharest<\/p>\n<p><strong>Project Manager: <\/strong>Assoc.Prof.PhD.Eng. Denisa FICAI<\/p>\n<p><strong>Scientific Researcher I:<\/strong> Prof.PhD.Eng. Ovidiu Cristian OPREA<\/p>\n<p><strong>Scientific Researcher III:<\/strong> SRIII.PhD.Eng. Bogdan \u0218tefan VASILE<\/p>\n<p><strong>PhD student: <\/strong>PhD.Stud.Eng. Cornelia Ioana ILIE<\/p>\n<p><strong>Scientific Researcher III: <\/strong>Lect.PhD.Eng. Ionela Andreea NEAC\u015eU<\/p>\n<p><strong>PhD student: <\/strong>PhD.Stud.Eng. Roxana Doina TRU\u0218C\u0102<\/p>\n<p><strong>PhD student: <\/strong>PhD.Stud.Eng. Georgiana DOLETE<\/p>\n<p><strong>PhD student: <\/strong>PhD.Stud.Eng. Ludmila MOTELIC\u0102<\/p>\n<p><strong>Scientific Researcher III: <\/strong>Lect.PhD.Eng. Adrian Vasile SURDU<\/p>\n<p><strong>Scientific Researcher<\/strong><strong>:<\/strong> PhD.Eng. Angela SPOIAL\u0102<\/p>\n<p><strong>PhD student: <\/strong>PhD.Stud.Eng. Alexa Maria CROITORU[\/vc_column_text][vc_separator color=&#8221;custom&#8221; accent_color=&#8221;#f3fbfe&#8221;][vc_column_text]<strong>Partner I (P1)<\/strong><strong>:<\/strong> <strong>National Institute for Research &amp; Development in Chemistry and Petrochemistry \u2013 ICECHIM<\/strong><\/p>\n<p><strong>Partner responsible: <\/strong>PhD.Eng. <strong>Irina FIERASCU (DUMITRU)<\/strong><\/p>\n<p><strong>Scientific Researcher<\/strong><strong> I:<\/strong> Phd. Radu Claudiu FIERASCU<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> I: <\/strong>Phd. Valentin RADI\u021aOIU<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> I: <\/strong>Phd. Cristian Andi NICOLAE<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> II: <\/strong>Phd. Raluca SOMOGHI<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> III: <\/strong>Phd. Elena CHICAN<\/p>\n<p><strong>Scientific research assistant: <\/strong>Phd. Roxana Ioana BRAZDIS<\/p>\n<p><strong>Scientific research assistant: <\/strong>Phd. Ana Maria BAROI<\/p>\n<p><strong>Scientific research assistant: <\/strong>Phd. Fristos TOMA[\/vc_column_text][vc_separator color=&#8221;custom&#8221; accent_color=&#8221;#f3fbfe&#8221;][vc_column_text]<strong>Partner II (P2)<\/strong><strong>: <\/strong>\u00a0Stefan S. Nicolau Institute of Virology (IVN)<\/p>\n<p><strong>Partner responsible: <\/strong>S.R.I.PhD.Eng. Coralia BLEOTU<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> II: <\/strong>Phd. Lilia MATEI<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> II: <\/strong>Phd. Laura NECULA<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> III: <\/strong>Phd. Denisa DRAGU<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> III: <\/strong>Phd. Ana NEAGU<\/p>\n<p><strong>PhD student: <\/strong>Phd.Stud. Ioana PITICA<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> III: <\/strong>Phd. Otilia BANU<\/p>\n<p><strong>Scientific Researcher<\/strong><strong> III: <\/strong>Phd. Gra\u021biela GR\u0102DI\u0218TEANU[\/vc_column_text][vc_separator color=&#8221;custom&#8221; accent_color=&#8221;#f3fbfe&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab show_icon=&#8221;yes&#8221; icon_type=&#8221;simpleline&#8221; icon_simpleline=&#8221;Simple-Line-Icons-target&#8221; title=&#8221;Project objective&#8221; tab_id=&#8221;1604406200212-2-10&#8243;][vc_column_text el_class=&#8221;justify&#8221;]<strong>Project objective<\/strong><\/p>\n<p>The aim of this project proposal is to develop new micro and mesoporous (MMM) materials using recent synthesis methods and to further functionalize these materials in order to improve their efficiency, so that they can be used as controlled release systems, in particular for diseases associated with the microbiota.<\/p>\n<p>These controlled release systems are developed for oral administration and are expected to be protected in the stomach and maintained until the desired target site is reached. Although these controlled release platforms are highly studied in the literature for several types of applications such as controlled release systems (which host antitumor, anti-infective or analgesic agents), the field of microbiota is studied very little.<\/p>\n<p>Nowadays, especially in children, awareness of the importance of the microbiota is well known; therefore, after treatment with antibiotics, it is often necessary to prescribe probiotics. Within the limits of the project, the natural substances used as biologically active agents will be loaded into the porous platforms, to ensure a positive feedback to the microbiota due to its antioxidant, antimicrobial, anti-inflammatory and anticancer activities. \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 In recent years, much emphasis has been placed on the development of micro- and mesoporous materials loaded with biologically active agents, but few scientific papers present the impact of functionalized MMMs on the microbiota.<\/p>\n<p>In this project, the main goal is to develop innovative MMMs with an improved pore system, capable of hosting and releasing biologically active agents (vitamins and polyphenols will be used) for the treatment of microbiota-related diseases.<\/p>\n<p>Because most polyphenols have a low solubility, two innovative controlled release systems will be developed in order to ensure intelligent release (to a target site).<\/p>\n<p>Therefore, in the current project, 3 general objectives (GO), achieved through several specific objectives (SO), have been taken into account, as follows:<\/p>\n<p>GO 1. Exploiting the results of research obtained by applicants for the establishment and development of new innovative delivery systems for biologically active species (medicines). This goal is achievable by pooling preliminary research results on micro and mesoporous materials used as drug delivery systems, along with modern functionalization techniques and biologically active natural agents, resulting in new treatment tools for gastrointestinal microbiota diseases.<\/p>\n<p>GO 2. Laboratory validation of a technology aimed at obtaining new biosystems, establishing and demonstrating the properties of final products and facilitating technology transfer. This goal will be achieved by manufacturing a final product consisting of a biocompatible drug delivery system and evaluating \u201cin vitro\u201d biological interactions along with the biochemical stability and drug release kinetics, bringing the concept closer to industrial application.<\/p>\n<p>GO 3. Consolidation and protection of intellectual property rights in relation to developed materials.[\/vc_column_text][\/vc_tab][vc_tab show_icon=&#8221;yes&#8221; icon_type=&#8221;simpleline&#8221; icon_simpleline=&#8221;Simple-Line-Icons-notebook&#8221; title=&#8221;Working plan&#8221; tab_id=&#8221;1604407317768-4-4&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;599&#8243; img_size=&#8221;full&#8221; css=&#8221;.vc_custom_1605772137580{margin-bottom: 35px !important;}&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;]<div class=\"porto-toggles wpb_content_element \" data-view=\"one-toggle\">[vc_toggle title=&#8221;WP 1: Preparation of micro and mesoporous materials&#8221;]<\/p>\n<ul>\n<li>Realization of a literature study to identify the most recent aspects published in the MMMs domain;<\/li>\n<li>Preliminary studies for synthesis of MMMs on the basis of silicon as a storage for different molecules, with more capacitance of loading and a regulatory eliberation mechanism;<\/li>\n<li>Preliminary studies on characterization, in terms of morphological and structural properties of MMMs (FTIR, SAXS, XRD, BET, SEM, ICP-MS, TEM, thermal analysis);<\/li>\n<li>Preliminary studies will allow the biological evaluation of natural or synthetic MMMs.<\/li>\n<\/ul>\n<p>[\/vc_toggle][vc_toggle title=&#8221;WP 2: Surface modification and development of MMM-based drug delivery systems.&#8221;]<\/p>\n<ul>\n<li>\u00a0Synthesis of silicon-based MMMs as storage sources of various molecules, with high loading capacity and adaptive release mechanisms;\u00b7<\/li>\n<li>Induction of porosity and size depending on the synthesis conditions (template agents, pH, phase diagram, etc.) to selectively load hydrophobic or hydrophilic substances;\u00b7<\/li>\n<li>Morphological and structural characterization of the obtained MMMs (FTIR, SAXS, XRD, BET, SEM, ICP-MS, TEM, thermal analysis);\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Biological evaluation of natural or synthetic MMMs;\u00b7<\/li>\n<li>\u00a0Development of protocols for characterizing silanized systems under controlled conditions (FTIR, DTA-TG, BET);\u00b7<\/li>\n<li>Loading and release of biologically active agents;\u00b7<\/li>\n<li>Assessing the loading and delivery capacity of medicines;\u00b7<\/li>\n<li>Biological evaluation performed to establish the cytotoxic and antimicrobial activity of the biologically active agents used and their influence on the intestinal microbiota.<\/li>\n<\/ul>\n<p>[\/vc_toggle][vc_toggle title=&#8221;WP 3: Implementation of mechanisms for controlling the release of drugs.&#8221;]<\/p>\n<ul>\n<li>Optimization of protocols according to existing data;\u00b7<\/li>\n<li>Co-charging of bivalent ions and biologically active agents for the development of MMMs charged with biologically active agents with improved properties;\u00b7<\/li>\n<li>Development of porous systems with &#8220;closed pore&#8221; morphology, loaded with biologically active agents;\u00b7<\/li>\n<li>Synthesis of magnetite in the pores of MMMs, followed by loading with biologically active agents;\u00b7<\/li>\n<li>Evaluation of triggered MMMs (FTIR, SEM, BET, XRD, DTA-TG);\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Evaluation of the release profile;\u00b7<\/li>\n<li>Completion of studies on the biological evaluation performed to establish the cytotoxic and antimicrobial activity of the biologically active agents used and their influence on the intestinal microbiota;<\/li>\n<\/ul>\n<p>[\/vc_toggle]<\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab show_icon=&#8221;yes&#8221; icon_type=&#8221;simpleline&#8221; icon_simpleline=&#8221;Simple-Line-Icons-pencil&#8221; title=&#8221;Results dissemination&#8221; tab_id=&#8221;1605536201272-3-1&#8243;][\/vc_tab][vc_tab show_icon=&#8221;yes&#8221; title=&#8221;Project partners&#8221; tab_id=&#8221;1607278745243-4-8&#8243; icon=&#8221;fas fa-globe&#8221;][vc_column_text]Partner (P1) &#8211; <strong>National Institute for Research &amp; Development in Chemistry and Petrochemistry \u2013 ICECHIM<\/strong><\/p>\n<p><strong>Partner (P2) &#8211; <\/strong>Stefan S. Nicolau Institute of Virology (IVN)[\/vc_column_text][\/vc_tab][\/vc_tabs][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row equal_height=&#8221;yes&#8221;][vc_column offset=&#8221;vc_col-md-8&#8243;][vc_single_image image=&#8221;665&#8243; img_size=&#8221;full&#8221;][\/vc_column][vc_column css=&#8221;.vc_custom_1605772046492{padding-top: 15px !important;background-color: #f3fbfe !important;}&#8221; offset=&#8221;vc_col-md-4&#8243;][\/vc_column][\/vc_row][vc_row el_class=&#8221;padding-65&#8243;][vc_column][vc_tabs type=&#8221;tabs-simple&#8221; icon_style=&#8221;featured-boxes-style-6&#8243; icon_effect=&#8221;featured-box-effect-6&#8243;][vc_tab show_icon=&#8221;yes&#8221; icon_type=&#8221;simpleline&#8221; icon_simpleline=&#8221;Simple-Line-Icons-people&#8221; title=&#8221;Project team&#8221; tab_id=&#8221;7224df3a-ec68-8&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;614&#8243; img_size=&#8221;full&#8221; css=&#8221;.vc_custom_1605772093012{margin-bottom: 35px !important;}&#8221;][\/vc_column_inner][vc_column_inner el_class=&#8221;echipa&#8221; width=&#8221;1\/2&#8243;][vc_column_text]Coordinator \u2013 University POLITEHNICA of Bucharest Project Manager: Assoc.Prof.PhD.Eng. Denisa FICAI Scientific Researcher I: Prof.PhD.Eng. Ovidiu Cristian OPREA Scientific Researcher III: SRIII.PhD.Eng. Bogdan \u0218tefan VASILE PhD student: [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":657,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,21],"tags":[],"class_list":["post-812","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-portofoliu-en","category-portofoliu-desfasurare-en"],"featured_image_src":{"landsacpe":["https:\/\/www.micronanotech.ro\/wp-content\/uploads\/2020\/11\/research-pic-tiny.jpg",600,400,false],"list":["https:\/\/www.micronanotech.ro\/wp-content\/uploads\/2020\/11\/research-pic-tiny-463x348.jpg",463,348,true],"medium":["https:\/\/www.micronanotech.ro\/wp-content\/uploads\/2020\/11\/research-pic-tiny-300x200.jpg",300,200,true],"full":["https:\/\/www.micronanotech.ro\/wp-content\/uploads\/2020\/11\/research-pic-tiny.jpg",600,400,false]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evaluation of the exploitation potential of porous materials in the treatment of microbiota dysbiosis - Micronanotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.micronanotech.ro\/en\/evaluarea-potentialului-de-exploatare-a-materialelor-poroase-in-tratarea-disbiozelor-microbiotei\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evaluation of the exploitation potential of porous materials in the treatment of microbiota dysbiosis - Micronanotech\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][\/vc_column][\/vc_row][vc_row equal_height=&#8221;yes&#8221;][vc_column offset=&#8221;vc_col-md-8&#8243;][vc_single_image image=&#8221;665&#8243; img_size=&#8221;full&#8221;][\/vc_column][vc_column css=&#8221;.vc_custom_1605772046492{padding-top: 15px !important;background-color: #f3fbfe !important;}&#8221; offset=&#8221;vc_col-md-4&#8243;][\/vc_column][\/vc_row][vc_row el_class=&#8221;padding-65&#8243;][vc_column][vc_tabs type=&#8221;tabs-simple&#8221; icon_style=&#8221;featured-boxes-style-6&#8243; icon_effect=&#8221;featured-box-effect-6&#8243;][vc_tab show_icon=&#8221;yes&#8221; icon_type=&#8221;simpleline&#8221; icon_simpleline=&#8221;Simple-Line-Icons-people&#8221; title=&#8221;Project team&#8221; tab_id=&#8221;7224df3a-ec68-8&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;614&#8243; img_size=&#8221;full&#8221; css=&#8221;.vc_custom_1605772093012{margin-bottom: 35px !important;}&#8221;][\/vc_column_inner][vc_column_inner el_class=&#8221;echipa&#8221; width=&#8221;1\/2&#8243;][vc_column_text]Coordinator \u2013 University POLITEHNICA of Bucharest Project Manager: Assoc.Prof.PhD.Eng. Denisa FICAI Scientific Researcher I: Prof.PhD.Eng. Ovidiu Cristian OPREA Scientific Researcher III: SRIII.PhD.Eng. 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Denisa FICAI Scientific Researcher I: Prof.PhD.Eng. Ovidiu Cristian OPREA Scientific Researcher III: SRIII.PhD.Eng. 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