- Abbreviation: MANAGEWOUND
- Project code: PN-III-P2-2.1-PED-2019-1375
- Contract number: 331PED/2020
- Start: 03 August 2020
End: 02 August 2022 - Duration: 24 months
- Budget: 600 000 RON
- Coordinating institution:University of Medicine and Pharmacy “Carol Davila” Bucharest
- Partner institution: UPB-CNMN – University POLITEHNICA of Bucharest – National
Center for Micro and Nanomaterials
Project Manager: Dr. Alina Mihaela PRODAN
Professor/ Research Member: Dr. Mircea BEURAN
Scientific Researcher I/Research Member: Phd. Daniela PREDOI
Scientific Researcher III/ Research Member: Phd. Simona Liliana ICONARU
University Lector/Research Member: Phd. Ionuț NEGOI
Scientific Researcher/Research Member: Dr. Mihai MATEI
Scientific Researcher/Research Member: Dr. Valentin ENACHE
Scientific research assistant/Research Member: Dr. Mihai Răzvan IONESCU
Scientific research assistant/Research Member: Dr. Alexandru STOIAN
Scientific research assistant/Research Member: Dr. Cezar CIUBOTARU
Scientific research assistant/Research Member: Dr. Bianca CÂNCEA
Scientific research assistant/Research Member: Dr. Claudiu Ștefan
Professor/ Partner responsible: Prof.PhD.Eng. Ecaterina ANDRONESCU
Scientific Researcher III/ Research Member: S.R.III.PhD.Eng. Bogdan Ștefan VASILE
University Associate Professor: Assoc.Prof.PhD.Eng. Denisa FICAI
PhD student/PhD Member: Lect.PhD.Eng. Ionela Andreea NEACŞU
PhD student/PhD Member: Lect.PhD.Eng. Vladimir Lucian ENE
PhD student/PhD Member: PhD.stud.Eng Alexandra Cătălina Bîrcă
Scientific research assistant/Research Member: PhD.stud.Eng Roxana Doina TRUȘCĂ
Technician III/Technician Member: Techn. Claudiu GIUȘCĂ
Project Objective
The main goal of this project is to solve an important health problem, that of wound infections.
Thus, this project has as main objective the development of ZnO powders for possible applications in the local treatment of wound infections. For the implementation of the project we will start from the experimental results already obtained in the consortium regarding the fundamental research on ZnO powders (TRL 2), thus developing a new experimental model of ZnO powders (TRL) 3).
Finally, the project implementation will be achieved by laboratory validation of the technology / product (TRL 4).
Testing and validation of laboratory models of ZnO powder type will be obtained by investigating the physicochemical properties and antimicrobial activity. In vivo tests for their antimycrobial activity will also be performed.
In addition, the behavior of ZnO under in vitro conditions will be observed by immersing them in a simulated physiological fluid (SBF) solution. On the other hand, comparative studies will be performed between the in vivo response to local treatment with betadine and hydrogen peroxide, respectively to the treatment with ZnO powders.
The general objective: the development of ZnO powders for possible applications in the local treatment of wound infections.
Specific objectives:
O1 – Development of the procedure for the synthesis of ZnO powders by the hydrothermal method and the hydrothermal method in the microwave field;
O2 – Chemical and morphological characterization of ZnO powders;
O3 – Elaboration of an experimental model by selecting the optimal synthesis conditions;
O4 – In vitro testing of ZnO powders by immersion in SBF solution;
O5 – Study of the physico-chemical properties of ZnO powders after immersion in SBF solution;
O6 – Development of a protocol for non-destructive analysis using ultrasonic measurements;
O7 – Local treatment with ZnO powders of wounds with artificially induced infection;
O8 – Histopathological studies of infected tissues prior to treatment with Betadine and ZnO powders;
O9 – Histopathological studies of infected tissues after treatment with Betadine and ZnO powders;
O10 – Development of a protocol for the local treatment with ZnO powders of wounds with artificially induced infection.
- ZnO powders;
- Experimental results on structure, morphology and composition
- ZnO powders;
- Optical properties;
- Biological properties of ZnO powders;
- Validation of results in EU laboratories;
- Website
- Porozitate material;
- Material porosity;
- Material density;
- Size distribution;
- Powders modified after immersion in SBF;
- Physico-chemical characterization of powders after immersion in SBF;
- Histopathological analysis;
- 1 article sent for publication;
- 1 participation in a scientific event;
- Validation of results in EU laboratories;
- Website update.
- Optical properties of selected materials;
- Biological properties of selected materials;
- 1 article sent for publication;
- 1 participation in a scientific event;
- Website update;
- Validation of experimental results in EU laboratories.
- Proprietăți optice ale materialelor selectate;
- Proprietăți biologice ale materialelor selectate;
- 1 articol trimis spre publicare;
- 1 participare la o manifestare științifică;
- Actualizare site web;
- Validare rezultate experimentale în laboratoare UE.
- Phase 1: Preliminary synthesis and characterization of ZnO powders
- Phase 2: Complex studies on the possibility of using ZnO powders for the treatment of artificially induced wound infection
- Phase 3: Development of optimal ZnO nanoparticles for antimicrobial applications