Nanostructured bone grafts with predetermined properties

Name Position in the project
Ficai Anton Principal Investigator
Viorel Nacu Responsabil Partener 1 (P1)
Ovidiu Cristian Oprea Membru-Cercetator
Cornelia-Ioana Ilie Membru-Doctorand
Angela Spoiala Membru-Cercetător postdoctoral
Ludmila Motelica Membru-Cercetător postdoctoral
Doina Fosa Membru-Doctorand
Mariana Jian Membru-Doctorand
Elena Pavlovschi Membru-Doctorand
The project proposal is especially focused on developing new synergies between Romania and Moldova by joining the force of two representative universities in developing high-quality research in one of the most challenging topics of tissue engineering, meaning hard tissue engineering. The importance of the topic is based on the very high need for bone-related materials (49% of the total market of grafting materials being represented by bone grafts) and, unfortunately, there are some diseases (osteosarcoma, infections, cancer) along with accidents that make necessary to develop more and more complex systems. Based on the existent, complementary experience of the UNSTPB (in the field of developing and morpho-structural, thermal characterisation of these materials) and USMF (especially in vitro and in vivo evaluation), the consortium will be able to develop complex and complete research. The materials will be designed with incremental complexity depending on the medical needs, from pure regenerative to enhanced regenerative (such for instance in the case of elderly people/people with osteoporosis) and up to complex drug delivery systems for the treatment of infections or cancer. The collaboration started before the bilateral project within an AUF program (with a 2-month internship of Mariana Jian within UNSTPB) and will continue within other bilateral projects of other funds being of mutual interest.

Stage 1:

The development of composite materials based on collagen and hydroxyapatite
Results
Submission of at least one review paper (D1.1);
participation in at least one international conference (D1.3);

Stage 2:

Development of systems with controlled release based on collagen, hydroxyapatite and mesoporous silica
Results
Development of at least 4 experimental models of mesoporous materials (D1.2 from the proposal) and composites (D2.2 from the proposal) 
The development of at least 3 porous materials loaded with antimicrobial, antitumor or just improved regeneration properties (D2.1 + D2.3)

Stage 3:

Evaluation of controlled release systems and drafting of developed product data sheets
Results
Submission of at least 2 research articles to relevant ISI journals (D2.4)
Experimental model with predefined release profile and trigger capability (D2.3)

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Papers

  1. Angela Spoiala, Mariana Jian, Doina Fosa, Denisa Ficai, Viorel Nacu, Anton Ficai, Composite-based biomaterials as bone grafts for tissue engineering applications and personalized medicine: A comprehensive review;

Conferences

  1. Mariana JIAN, Andreea-Isabela LAZAR, Ludmila MOTELICA, Angela SPOIALA, Vitalie COBZAC, Denisa FICAI, Ovidiu OPREA, Viorel NACU, Anton FICAI. Sustainable Approaches in Designing Biomaterials and Devices for Tissue Engineering. UNAM International Engineering Conference on Sustainable Emerging Innovations and Technological Advancements. University of Namibia, 02-04 December 2024 (plenary lecture).
  2. JIAN, M., MOSTOVEI, A., COBZAC, V., NACU, A-M., MOTELICA, L., OPREA, C. O., FICAI, D., FICAI, A., NACU, V. Three-dimensional collagen scaffolds for applications in tissue engineering. In: Abstract book. 32nd Annual Congress of the European Association of Tissue and Cell Banks 2024. Barcelona, Spain. 28-29 November 2024, p. 64.
  3. Anton FICAI et al. Processing and Design of Materials for Bone Tissue Engineering; “Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2024 – Winter Edition; 27-29 November 2024 (plenary lecture).
  4. Mariana JIAN, Isabela LAZAR, Denisa FICAI, Viorel NACU, Anton FICAI. Smart Drug Delivery Systems and Personalized Therapies; 28th Internatinal Biomedical Science & Technology Symposium; 1-3 November 2024, Kocaeli, Türkiye (Invited lecture).
  5. Anton FICAI et al. Material Design for the Sustainable Development of Bone Grafting; Ediția a 7-a a Conferinței Internaționale Tehnologii Emergente în Ingineria Materialelor; 30 – 31 Octombrie 2024 – hotel Marshal Garden, București, România (plenary lecture).

Patentes

Mariana JIAN, Anton FICAI, Denisa FICAI, Viorel NACU, Vitalie COBZAC, Ludmila MOTELICA, Andrei MOSTOVEI, Ovidiu Cristian OPREA si Oleg SOLOMON. Grefă osoasă nanostructurată; AGEPI, 6291/29.10.2024

Awards

Medalie Aur – International Innovation and Invention Show Euro POLITEHNICUS 2024

Thailand Award for the Best International Invention &Innovation